Number three seed, Stan Wawrinka, has crashed out of the Madrid Open after he was defeated by world number 52, Benoit Paire 7-5 4-6 6-2.
Wawrinka becomes the first big-name casualty of the men’s tournament with Murray, Djokovic and Nadal all making it through to the third round.
Prior to tie, the pair had met a total of nine times with the Swiss world number three coming out tops on seven occasions, leaving the 28-year-old Frenchman with two previous wins.
