
Goals from Neymar and Alexis Sanchez ensured Gerardo Martino won his first Classico in charge of Barcelona as they ran out 2-1 winners.
Jese Rodriguez scored a late consolation for Los Blancos, but the damage had already been done.
The win moves Barcelona four points clear of Atletico Madrid at the top of the La Liga, and six points ahead of their rivals, Real Madrid.